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前瞻性脊柱治疗结果研究的两年结果:对颈椎病性脊髓病手术治疗的并发症发生率、并发症发生的预测因素及其对患者两年衍生结局的影响的分析

Two-Year Results of the Prospective Spine Treatment Outcomes Study: An Analysis of Complication Rates, Predictors of Their Development, and Effect on Patient Derived Outcomes at 2 Years for Surgical Management of Cervical Spondylotic Myelopathy.

作者信息

Gerling Michael C, Radcliff Kris, Isaacs Robert, Bianco Kristina, Jalai Cyrus M, Worley Nancy J, Parmar Jaspreet, Poorman Gregory W, Horn Samantha R, Moon John Y, Arnold Paul M, Vaccaro Alexander R, Passias Peter

机构信息

Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, New York, USA.

Department of Orthopaedics, The Rothman Institute, Egg Harbor, New Jersey, USA.

出版信息

World Neurosurg. 2017 Oct;106:247-253. doi: 10.1016/j.wneu.2017.06.147. Epub 2017 Jul 1.

Abstract

OBJECTIVES

To investigate the baseline patient characteristics, nonoperative modalities, surgical procedures, and complications rates of surgical cervical spondylotic myelopathy (CSM) patients. To evaluate risk factors for developing complications and compare the changes in health-related quality of life (HRQOL) from baseline to 2 years postoperatively.

METHODS

A retrospective review was performed on a prospectively collected database of CSM patients. Baseline patient demographic data, comorbidities, clinical information, nonoperative treatment modalities, surgical procedures, and complication rates were collected. HRQOL outcomes were assessed using the Short Form 36 (SF-36) Physical Score Component (PCS) and Mental Score Component (MCS) and the Neck Disability Index (NDI) at baseline and 2 years postoperatively. Statistical analyses included paired-sample t tests and multivariate logistic regression controlling for age, sex, and body mass index (BMI).

RESULTS

A total of 203 surgical CSM patients were identified (43% female). Average age was 57.7 years and average BMI was 29.6 kg/m. Before surgical intervention, patients underwent various nonoperative treatment modalities, most commonly nonsteroidal anti-inflammatory drugs (34%), analgesics (32%), and physical therapy (26%). The overall rate of complications was 7.4%. Complications included cerebrospinal fluid leak (2.5%), postoperative radiculopathy (1.0%), and excessive bleeding (1.0%). A previous history of cervical spine surgery was the sole significant risk factor for developing a complication (odds ratio, 9.22; P = 0.034). Average HRQOL scores improved significantly from baseline to 2 years postsurgery.

CONCLUSIONS

The overall complication rate was 7.4% for the cohort. Baseline clinical information, comorbidities, use of nonoperative treatment modalities, and procedure type were not significantly associated with an increased risk of complications. Previous cervical spine surgery increased the risk of complications by 9-fold. The patients showed significantly improved SF-36 PCS, SF-36 MCS, and NDI scores at 2 years after surgery.

摘要

目的

调查手术治疗的脊髓型颈椎病(CSM)患者的基线患者特征、非手术治疗方式、手术操作及并发症发生率。评估发生并发症的危险因素,并比较从基线到术后2年健康相关生活质量(HRQOL)的变化。

方法

对前瞻性收集的CSM患者数据库进行回顾性研究。收集患者的基线人口统计学数据、合并症、临床信息、非手术治疗方式、手术操作及并发症发生率。在基线和术后2年,使用简短健康调查问卷36(SF-36)身体评分组件(PCS)、精神评分组件(MCS)和颈部功能障碍指数(NDI)评估HRQOL结果。统计分析包括配对样本t检验和控制年龄、性别和体重指数(BMI)的多因素逻辑回归。

结果

共确定203例接受手术治疗的CSM患者(43%为女性)。平均年龄为57.7岁,平均BMI为29.6kg/m。在手术干预前,患者接受了各种非手术治疗方式,最常见的是非甾体抗炎药(34%)、镇痛药(32%)和物理治疗(26%)。总体并发症发生率为7.4%。并发症包括脑脊液漏(2.5%)、术后神经根病(1.0%)和出血过多(1.0%)。既往颈椎手术史是发生并发症的唯一显著危险因素(比值比,9.22;P=0.034)。从基线到术后2年,平均HRQOL评分显著改善。

结论

该队列的总体并发症发生率为7.4%。基线临床信息、合并症、非手术治疗方式的使用和手术类型与并发症风险增加无显著相关性。既往颈椎手术使并发症风险增加9倍。患者在术后2年时,SF-36 PCS、SF-36 MCS和NDI评分显著改善。

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