高铁血红蛋白：一种区分烧伤深度的新方法。

Methemoglobin: A New Way to Distinguish Burn Depth.

作者信息

Saiko Guennadi

机构信息

Department of Physics, Ryerson University, Toronto, ON, Canada.

出版信息

Adv Exp Med Biol. 2017;977:359-365. doi: 10.1007/978-3-319-55231-6_47.

DOI:10.1007/978-3-319-55231-6_47

PMID:28685466

Abstract

UNLABELLED

In this work, we present a model of dynamics of methemoglobin (MetHb) in burn injuries and show that measuring levels of MetHb can distinguish thickness in burn injuries.

METHODS

The model of dynamics of MetHb levels in blood of subjects with burn injuries has been developed based on the vascular morphology of the skin. The model contains burn-specific and non-specific components.

RESULTS

The model predicts three distinct outcomes: (a) superficial burn, where the superficial plexus is mainly intact, (b) partial thickness burn, where the superficial plexus lies within the zone of coagulation, but the deep plexus is mainly intact, and (c) full depth burn, where the deep plexus lies in the zone of coagulation. The use of MetHb as a marker of burn injury has not just anatomical, but also physiological justification. The model is in qualitative agreement with a clinical study and an animal model (Yorkshire swine), which used Near Infrared Spectroscopy to assess MetHb levels in burns.

CONCLUSIONS

MetHb level in burn injuries is a physiological variable that can be used to classify burn injuries.

摘要

未标注

在本研究中，我们提出了一个烧伤患者高铁血红蛋白（MetHb）动力学模型，并表明测量MetHb水平可区分烧伤深度。

方法

基于皮肤的血管形态建立了烧伤患者血液中MetHb水平的动力学模型。该模型包含烧伤特异性和非特异性成分。

结果

该模型预测了三种不同的结果：（a）浅度烧伤，浅表血管丛基本完整；（b）部分厚度烧伤，浅表血管丛位于凝固区内，但深部血管丛基本完整；（c）深度烧伤，深部血管丛位于凝固区内。将MetHb用作烧伤损伤标志物不仅有解剖学依据，还有生理学依据。该模型与一项临床研究和一个动物模型（约克郡猪）在定性上一致，后者使用近红外光谱法评估烧伤中的MetHb水平。