Holmqvist Jämsen Sofia, Johansson Ada, Westberg Lars, Santtila Pekka, von der Pahlen Bettina, Simberg Susanna
Faculty of Arts, Psychology and Theology, Åbo Akademi University, Turku, Finland.
Faculty of Arts, Psychology and Theology, Åbo Akademi University, Turku, FinlandDepartment of Psychology and Speech-Language Pathology, Faculty of Social Sciences, University of Turku, FinlandDepartment of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden.
J Speech Lang Hear Res. 2017 Jul 12;60(7):1843-1854. doi: 10.1044/2016_JSLHR-S-16-0059.
Oxytocin and arginine vasopressin are associated with different aspects of the stress response. As stress is regarded as a risk factor for vocal symptoms, we wanted to explore the association between the oxytocin receptor gene (OXTR) and arginine vasopressin 1A receptor gene (AVPR1A) single-nucleotide polymorphisms (SNPs) and vocal symptoms. We also wanted to explore whether such effects might be mediated by cortisol because oxytocin and vasopressin are associated with cortisol levels.
A population-based sample (N = 657) of Finnish twins (born 1961-1989) completed a web questionnaire on the occurrence of vocal symptoms. A total of 170 participants submitted saliva samples for hormone analysis. A total of 20 OXTR and AVPR1A SNPs were analyzed.
Three OXTR polymorphisms (rs2270465, rs2268493, rs7632287) and 2 AVPR1A polymorphisms (rs1587097, rs1042615) showed nominal effects (p < .05) on vocal symptoms, of which 1 (rs1587097) remained significant after correcting for multiple testing (p = .003). We found potential mediation of the effect of the OXTR rs2268493 polymorphism on vocal symptoms through levels of cortisol.
The associations between variants of OXTR and AVPR1A and vocal symptoms indicate that oxytocin and vasopressin might influence vocal symptoms. The effect of oxytocin seems to be partly mediated through cortisol actions.
催产素和精氨酸加压素与应激反应的不同方面相关。由于应激被视为嗓音症状的一个风险因素，我们想要探究催产素受体基因（OXTR）和精氨酸加压素1A受体基因（AVPR1A）单核苷酸多态性（SNP）与嗓音症状之间的关联。我们还想要探究此类效应是否可能由皮质醇介导，因为催产素和加压素与皮质醇水平相关。
一个基于人群的芬兰双胞胎样本（N = 657，出生于1961 - 1989年）完成了一份关于嗓音症状发生情况的网络问卷。共有170名参与者提交了唾液样本用于激素分析。总共分析了20个OXTR和AVPR1A的SNP。
三个OXTR多态性位点（rs2270465、rs2268493、rs7632287）和两个AVPR1A多态性位点（rs1587097、rs1042615）对嗓音症状显示出名义效应（p <.05），其中一个（rs1587097）在多重检验校正后仍具有显著性（p =.003）。我们发现OXTR rs2268493多态性对嗓音症状的效应可能通过皮质醇水平介导。
OXTR和AVPR1A的变体与嗓音症状之间的关联表明，催产素和加压素可能影响嗓音症状。催产素的效应似乎部分通过皮质醇作用介导。
Zotero 插件