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胰管结石:16例报告

Pancreatic duct stones: A report on 16 cases.

作者信息

Panek-Jeziorna Magdalena, Wierzbicki Jarosław, Annabhani Abdulhabib, Paradowski Leszek, Mulak Agata

机构信息

Department of Gastroenterology and Hepatology, Wroclaw Medical University, Poland.

Department of Minimally Invasive Surgery and Proctology, Wroclaw Medical University, Poland.

出版信息

Adv Clin Exp Med. 2017 Jul;26(4):609-613. doi: 10.17219/acem/62687.

Abstract

BACKGROUND

Pancreatolithiasis occurs in less than 1% of the general population and is mainly recognized in patients with chronic pancreatitis. Selection of the appropriate treatment method depends on the location, size and number of stones.

OBJECTIVES

The aim of the study was to analyze data concerning patients with pancreatic duct stones who were hospitalized at Wroclaw Medical University's Department of Gastroenterology and Hepatology from 2010 to 2014.

MATERIAL AND METHODS

The study presents data on 16 patients with pancreatic duct stones, who constituted 7% of all 228 patients with chronic pancreatitis hospitalized at the Department in the study period. The clinical data were compared with findings reported in the literature.

RESULTS

Epigastric pain was the most common symptom reported by patients with pancreatolithiasis. The sensitivity of imaging tests in the diagnosis of pancreatic duct stones was as follows: abdominal ultrasonography - 31%, endoscopic retrograde cholangiopancreatography (ERCP) - 67%, computed tomography - 71%, endoscopic ultrasonography - 73%. In 6 patients ERCP and sphincterotomy were performed along with stenting of the main pancreatic duct. Three other subjects were qualified for surgical treatment. In 7 selected patients conservative treatment and further observation were applied.

CONCLUSIONS

Endoscopic ultrasonography is characterized by high sensitivity in the diagnosis of pancreatic duct stones. ERCP is the first-line treatment in the case of a small number of stones with sizes below 5 mm located in the head or body of the pancreas. In the case of stones with sizes ≥ 5 mm, extracorporeal shock wave lithotripsy should be performed before endoscopic drainage during ERCP. Stenosis of the main pancreatic duct is the key risk factor for the recurrence of pancreatolithiasis.

摘要

背景

胰腺结石在普通人群中的发生率低于1%,主要在慢性胰腺炎患者中被发现。合适治疗方法的选择取决于结石的位置、大小和数量。

目的

本研究旨在分析2010年至2014年在弗罗茨瓦夫医科大学胃肠病学和肝病学系住院的胰腺导管结石患者的数据。

材料与方法

该研究展示了16例胰腺导管结石患者的数据,这些患者占该研究期间在该科室住院的所有228例慢性胰腺炎患者的7%。将临床数据与文献报道的结果进行了比较。

结果

上腹部疼痛是胰腺结石患者最常见的症状。成像检查对胰腺导管结石诊断的敏感性如下:腹部超声 - 31%,内镜逆行胰胆管造影(ERCP) - 67%,计算机断层扫描 - 71%,内镜超声 - 73%。6例患者进行了ERCP和括约肌切开术,并同时对主胰管进行了支架置入。另外3例患者符合手术治疗条件。7例选定患者采用了保守治疗和进一步观察。

结论

内镜超声在胰腺导管结石诊断中具有高敏感性。对于位于胰头或胰体的少量直径小于5mm的结石,ERCP是一线治疗方法。对于直径≥5mm的结石,在ERCP进行内镜引流前应先进行体外冲击波碎石术。主胰管狭窄是胰腺结石复发的关键危险因素。

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