O'Neill R D
Neurosci Lett. 1986 Jan 2;63(1):11-6. doi: 10.1016/0304-3940(86)90004-2.
Linear sweep voltammetry with carbon-paste electrodes was used to record simultaneously changes in the extracellular concentration of ascorbic acid, uric acid and homovanillic acid (HVA) in the striatum of unanaesthetized rats. The ascorbate signal was used as an index of excitatory amino acid release, whereas the HVA signal reflects changes in dopamine release. Microinjection of 2-chloroadenosine depressed both the ascorbate and the HVA signals; the infusion of adenosine deaminase increased the amplitude of the two signals. These results, considered in the light of lesion + binding studies, suggest that released endogenous adenosine may modulate the release of transmitter from both corticostriatal and nigrostriatal terminals. The effect of adenosine deaminase on the urate signal provides preliminary evidence that changes in this signal may reflect variations in the release of adenosine.
采用碳糊电极线性扫描伏安法同时记录未麻醉大鼠纹状体中抗坏血酸、尿酸和高香草酸（HVA）细胞外浓度的变化。抗坏血酸信号用作兴奋性氨基酸释放的指标，而HVA信号反映多巴胺释放的变化。微量注射2-氯腺苷可降低抗坏血酸和HVA信号；注入腺苷脱氨酶可增加这两种信号的幅度。结合损伤+结合研究来看，这些结果表明，释放的内源性腺苷可能调节来自皮质纹状体和黑质纹状体终末的神经递质释放。腺苷脱氨酶对尿酸信号的影响提供了初步证据，表明该信号的变化可能反映腺苷释放的变化。
