Almas Aysha, Moller Jette, Iqbal Romaina, Forsell Yvonne
Department of Public Health Sciences, Karolinska Institutet, 171 77, Stockholm, Sweden.
Department of Medicine, Aga Khan University, Karachi, Pakistan.
BMC Cardiovasc Disord. 2017 Jul 11;17(1):185. doi: 10.1186/s12872-017-0604-4.
The relationship between neuroticism, depression and cardiovascular disease (CVD) is complex and has so far not been studied in depth. The aim of this study was to determine if neuroticism is an effect-modifier in the association between depression and CVD. Data derived from a longitudinal cohort study on mental health, work and relations among adults (20-64 years), including 10,443 individuals. Depression was assessed using the Major Depression Inventory (MDI) and neuroticism by the Swedish Scale of Personality (SSP). Outcomes of cardiovascular disease were register-based from the National inpatient register.
Both depression (OR 1.9 (95%CI 1.4, 2.5)) and high levels of neuroticism (OR 1.2 (95%CI 1.1-1.3)) were associated with increased risk of CVD. The combined effect of depression and neuroticism on the risk of CVD revealed HRs ranging from 1.0 to 1.9 after adjusting for age and gender, socioeconomic position, prevalent hypertension and diabetes. Almost similar associations were seen after further adjustment for lifestyle factors.
Neuroticism increased the risk of CVD in depressed persons. We found synergistic interaction between neuroticism and depression status in predicting future risk of CVD.
神经质、抑郁与心血管疾病（CVD）之间的关系较为复杂，迄今为止尚未得到深入研究。本研究的目的是确定神经质是否为抑郁与心血管疾病之间关联的效应修饰因素。数据源自一项关于成年人（20 - 64岁）心理健康、工作及人际关系的纵向队列研究，共纳入10443名个体。使用重度抑郁量表（MDI）评估抑郁情况，通过瑞典人格量表（SSP）评估神经质。心血管疾病的结局基于国家住院登记系统的数据。
抑郁（比值比1.9（95%置信区间1.4, 2.5））和高水平神经质（比值比1.2（95%置信区间1.1 - 1.3））均与心血管疾病风险增加相关。在调整年龄、性别、社会经济地位、高血压和糖尿病患病率后，抑郁和神经质对心血管疾病风险的联合效应显示风险比在1.0至1.9之间。在进一步调整生活方式因素后，观察到几乎相似的关联。
神经质增加了抑郁症患者患心血管疾病的风险。我们发现神经质与抑郁状态在预测未来心血管疾病风险方面存在协同相互作用。
