中和威胁：泛埃博拉病毒抗体形成闭环。
Neutralizing the Threat: Pan-Ebolavirus Antibodies Close the Loop.
作者信息
Mire Chad E, Geisbert Thomas W
机构信息
Galveston National Laboratory, Galveston, TX, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
出版信息
Trends Mol Med. 2017 Aug;23(8):669-671. doi: 10.1016/j.molmed.2017.06.008. Epub 2017 Jul 8.
Abstract
The glycoprotein (GP) of ebolaviruses participates in a critical membrane fusion process to establish infection of a cell and therefore, represents an important target of both vaccines and antivirals. The latest reports on pan-ebolavirus monoclonal antibodies in small animal models may offer promising outcomes and insight into how best to target the GP in vaccine and antiviral discovery.
摘要
埃博拉病毒的糖蛋白（GP）参与关键的膜融合过程以建立细胞感染，因此，它是疫苗和抗病毒药物的重要靶点。关于泛埃博拉病毒单克隆抗体在小动物模型中的最新报告可能会带来有前景的结果，并为在疫苗和抗病毒药物研发中如何最佳地靶向GP提供见解。
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