Department of Physical Examination, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People's Republic of China.
Infectious Diseases Department, The People's Hospital of Yubei, District of Chongqing city, Chongqing, 401120, People's Republic of China.
Acta Diabetol. 2017 Oct;54(10):905-911. doi: 10.1007/s00592-017-1024-8. Epub 2017 Jul 12.
The ZJU index is a novel model for detecting non-alcoholic fatty liver disease (NAFLD) that it is calculated based on combination of the body mass index, fasting plasma glucose, triglycerides, and the serum alanine aminotransferase-to-aspartate transaminase ratio. We aimed to evaluate the diagnostic accuracy of the ZJU index in detecting NAFLD in the Chinese population.
This was a cross-sectional study. Anthropometric measurements, laboratory data, and ultrasonography features were collected through a standard protocol. The ZJU index, fatty liver index, hepatic steatosis index, lipid accumulation product, and visceral adiposity index were calculated. Then the predictive values of the five indices were compared according to the area under receiver-operating characteristic curve (AUROC) values.
A total of 19,804 participants were recruited, of whom 7324 participants were diagnosed with NFALD and 12,480 subjects were regarded as controls. The AUROC value for NAFLD identification by the ZJU index was 0.925 (95% confidence interval [CI]: 0.919-0.931), which was significantly higher than the values for the other four models (P < 0.001). Furthermore, from age 31 years to >60 years, the AUROC for the ZJU increased from 87.1 to 95.4%, values which were also greater than those for the other four indices. Analysis by sex also showed that the performance of the ZJU index in males and females was better than that of the other four indices.
The ZJU index is an accurate and easy to employ tool for identifying NAFLD in the general Chinese population.
ZJU 指数是一种新型的非酒精性脂肪性肝病（NAFLD）检测模型，它是基于体重指数、空腹血糖、甘油三酯和血清丙氨酸氨基转移酶/天冬氨酸氨基转移酶比值的组合计算得出的。我们旨在评估 ZJU 指数在中国人群中检测 NAFLD 的诊断准确性。
这是一项横断面研究。通过标准方案收集人体测量学指标、实验室数据和超声特征。计算 ZJU 指数、脂肪肝指数、肝脂肪变性指数、脂质堆积产物和内脏脂肪指数。然后根据受试者工作特征曲线（AUROC）值比较五个指数的预测值。
共招募了 19804 名参与者，其中 7324 名参与者被诊断为 NFALD，12480 名参与者被视为对照。ZJU 指数识别 NAFLD 的 AUROC 值为 0.925（95%置信区间[CI]：0.919-0.931），显著高于其他四个模型（P<0.001）。此外，从 31 岁到>60 岁，ZJU 的 AUROC 从 87.1%增加到 95.4%，其值也大于其他四个指数。按性别分析也表明，ZJU 指数在男性和女性中的表现优于其他四个指数。
ZJU 指数是一种准确且易于使用的工具，可用于识别中国一般人群中的 NAFLD。
