无先兆偏头痛发作的动脉自旋标记磁共振成像灌注研究
An Arterial Spin Labeling MRI Perfusion Study of Migraine without Aura Attacks.
作者信息
Gil-Gouveia Raquel, Pinto Joana, Figueiredo Patricia, Vilela Pedro Ferro, Martins Isabel Pavão
机构信息
Headache Center, Hospital da Luz, Lisboa, Portugal.
Institute for Systems and Robotics - Lisboa and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.
出版信息
Front Neurol. 2017 Jun 28;8:280. doi: 10.3389/fneur.2017.00280. eCollection 2017.
BACKGROUND
Studies of brain perfusion during migraine without aura attacks have inconsistent results.
METHODS
Arterial spin labeling MRI, a non-invasive quantitative perfusion technique, was used to prospectively study a spontaneous untreated migraine without aura attack and a headache-free period. Image analysis used FSL and MATLAB software; Group analysis used permutation methods for perfusion differences between sessions.
RESULTS
Thirteen women (age 35.7) were scanned during an attack of an average intensity of 6.8 (on 0-10 Visual Analog Scale) and 16 h duration. No global or regional perfusion differences were identified when comparing migraine and migraine-free sessions.
DISCUSSION
Our findings suggest that the painful phase of migraine without aura attacks is not associated with brain perfusion abnormalities.
背景
无先兆偏头痛发作期间脑灌注的研究结果并不一致。
方法
动脉自旋标记磁共振成像（一种非侵入性定量灌注技术）被用于前瞻性研究一次未经治疗的自发性无先兆偏头痛发作及一段无头痛期。图像分析使用FSL和MATLAB软件；组间分析采用置换方法来分析各时段之间的灌注差异。
结果
13名女性（年龄35.7岁）在一次平均强度为6.8（采用0至10视觉模拟量表）且持续16小时的发作期间接受了扫描。在比较偏头痛发作期和无偏头痛期时，未发现整体或局部灌注差异。
讨论
我们的研究结果表明，无先兆偏头痛的疼痛阶段与脑灌注异常无关。
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