Maulucci Francesco, Benninger David, Démonet Jean-François, Du Pasquier Renaud A, Hirt Lorenz, Hottinger Andreas, Kuntzer Thierry, Michel Patrik, Nater Bernard, Novy Jan, Rossetti Andrea O, Schluep Myriam, Vingerhoets François J G
Service de neurologie, Département des neurosciences cliniques, CHUV, 1011 Lausanne.
Rev Med Suisse. 2017 Jan 11;13(544-545):79-83.
Aducanumab reduces the burden of amyloid plaques in Alzheimer's disease, with significant improvement of clinical scores. Endovascular thrombectomy is recommended in patients with acute stroke with proximal occlusion of the anterior circulation. CGRP antagonists and botulinum toxin are effective in migraine. ZIKA virus infection has been linked to the Guillain-Barré syndrome. Edaravone has been approved for amyotrophic lateral sclerosis. Two monoclonal antibodies (ocrelizumab and daclizumab) and siponimod show positive results in multiple sclerosis. Thalamotomy of ventral intermediate nucleus (by gamma-knife or by magnetic resonance-guided focused ultrasound) is effective in drug-resistant essential tremor. The dose-dependent risk of foetal malformations associated with valproate and topiramate is confirmed.
阿杜卡努单抗可减轻阿尔茨海默病中淀粉样斑块的负担,并显著改善临床评分。对于急性前循环近端闭塞性卒中患者,推荐进行血管内血栓切除术。降钙素基因相关肽拮抗剂和肉毒杆菌毒素对偏头痛有效。寨卡病毒感染与吉兰 - 巴雷综合征有关。依达拉奉已被批准用于肌萎缩侧索硬化症。两种单克隆抗体(奥瑞珠单抗和达利珠单抗)以及西波尼莫德在多发性硬化症中显示出阳性结果。腹中间核丘脑切开术(通过伽玛刀或磁共振引导聚焦超声)对耐药性特发性震颤有效。丙戊酸盐和托吡酯与胎儿畸形相关的剂量依赖性风险已得到证实。