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利用纳米材料开发抗真菌疗法。

Development of antifungal therapies using nanomaterials.

机构信息

Department of Microbiological & Nanobiomedical Engineering, Medical University of Białystok, 15-222 Białystok, Poland.

Department Microbiology & Immunology, The Faculty of Health Sciences of the Jan Kochanowski University in Kielce, 25-317 Kielce, Poland.

出版信息

Nanomedicine (Lond). 2017 Aug;12(15):1891-1905. doi: 10.2217/nnm-2017-0052. Epub 2017 Jul 13.

Abstract

The number and diversity of chemical structures currently available as antibacterial drugs is much higher compared with the number of active substances in relation to pathogenic fungi. In this review we focus on nanotechnology approaches, which offer promising strategies to create nanoagents that possess broad-spectrum antifungal activity and might overcome mechanisms of antibiotic resistance. Special attention was given to magnetic nanoparticles and their ability to restrict fungal growth directly, which depends on surface chemistry and pathogen strains. We speculate that future developments of new antifungal methods will take advantage of the current knowledge of using of magnetic nanomaterials as anticancer agents based on their ability to induce hyperthermia and enhance photosensitizing processes.

摘要

与抗真菌药物相比,目前可用于抗菌药物的化学结构的数量和多样性要高得多。在这篇综述中,我们专注于纳米技术方法,这些方法为创造具有广谱抗真菌活性并可能克服抗生素耐药机制的纳米制剂提供了有前景的策略。特别关注磁性纳米粒子及其直接限制真菌生长的能力,这取决于表面化学和病原体菌株。我们推测,未来新的抗真菌方法的发展将利用当前使用磁性纳米材料作为抗癌剂的知识,基于它们诱导高热和增强光致敏过程的能力。

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