Nosratabadi Reza, Alavian Seyed Moayed, Zare-Bidaki Mohammad, Shahrokhi Vahid Mohammadi, Arababadi Mohammad Kazemi
Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Dept. of Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Mol Immunol. 2017 Oct;90:64-73. doi: 10.1016/j.molimm.2017.07.002. Epub 2017 Jul 10.
Innate immunity consists of several kinds of pathogen recognition receptors (PRRs), which participate in the recognition of pathogens and consequently activation of innate immune system against pathogens. Recently, several investigations reported that PRRs may also play key roles in the induction/stimulation of immune system related complications in microbial infections. Hepatitis B virus (HBV), as the main cause of viral hepatitis in human, can induce several clinical forms of hepatitis B and also might be associated with hepatic complications such as cirrhosis and hepatocellular carcinoma (HCC). Based on the important roles of PRRs in the eradication of microbial infections including viral infections and their related complications, it appears that the molecules may be a main part of immune responses against viral infections including HBV and participate in the HBV related complications. Thus, this review article has brought together information regarding the roles of PRRs in immunity against HBV and its complications.
固有免疫由多种病原体识别受体（PRR）组成，这些受体参与病原体的识别，并因此激活针对病原体的固有免疫系统。最近，多项研究报告称，PRR在微生物感染中免疫系统相关并发症的诱导/刺激过程中也可能发挥关键作用。乙型肝炎病毒（HBV）作为人类病毒性肝炎的主要病因，可引发多种临床类型的乙型肝炎，还可能与肝硬化和肝细胞癌（HCC）等肝脏并发症有关。鉴于PRR在根除包括病毒感染及其相关并发症在内的微生物感染中发挥的重要作用，这些分子似乎可能是针对包括HBV在内病毒感染的免疫反应的主要组成部分，并参与HBV相关并发症。因此，这篇综述文章汇集了有关PRR在抗HBV免疫及其并发症中作用的信息。
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