Fischer G, Hartmann H, Droese M, Schauer A, Bock K W
Virchows Arch B Cell Pathol Incl Mol Pathol. 1986;50(4):321-37. doi: 10.1007/BF02889911.
Localized areas with altered enzyme patterns were observed in liver tissue surrounding focal nodular hyperplasia in women after long-term use of oral contraceptives. These localized lesions were of three different types. Type I lesions were characterized by glycogen storage, a reduction in ATPase and an increase in gamma-glutamyltranspeptidase (gamma-GT) and UDP-glucuronyltransferase (UDP-GT) detected immunohistochemically. Type II lesions, which were morphologically very similar to small hyperplastic nodules, showed only a decreased ATPase reaction. Type III lesions showed an increase in gamma-GT (detected histochemically) and a slight reduction in ATPase. The results indicated that in human liver from patients given oral contraceptives long-term, localized lesions with altered enzyme patterns may occur which are very similar to those observed in animal models during experimental hepatic carcinogenesis.
长期使用口服避孕药的女性，在局灶性结节性增生周围的肝组织中观察到酶模式改变的局部区域。这些局部病变有三种不同类型。I型病变的特征是糖原储存、ATP酶减少，免疫组化检测显示γ-谷氨酰转肽酶（γ-GT）和UDP-葡糖醛酸基转移酶（UDP-GT）增加。II型病变在形态上与小的增生性结节非常相似，仅显示ATP酶反应降低。III型病变显示γ-GT增加（组织化学检测）和ATP酶略有降低。结果表明，在长期服用口服避孕药患者的人肝脏中，可能会出现酶模式改变的局部病变，这些病变与实验性肝癌发生过程中在动物模型中观察到的病变非常相似。
