Hegde Akshaya, Soh Yee Poh, Mitra Rupshi
School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.
Int J Environ Res Public Health. 2017 Jul 14;14(7):779. doi: 10.3390/ijerph14070779.
Animals cope with changing environments through changes in behavior. Such plasticity is, however, marked by substantial inter-individual variability. Neuroendocrine reactivity to challenging environments can be an important predictor of resilience. Both basolateral amygdala (BLA) neurons and adrenal glucocorticoid signaling are integral parts of the stress neuroendocrine response. In this report, we test if individual variation in hormonal response to stress is associated with individual variation in the dendritic complexity of BLA neurons. We report a positive correlation between inter-individual variability in glucocorticoid response and neuronal plasticity in the BLA subsequent to a stressor. This suggests that stressful experiences in the past act as significant sculptors of BLA neuronal plasticity and congruent neuroendocrine response.
动物通过行为变化来应对不断变化的环境。然而，这种可塑性存在显著的个体间差异。对挑战性环境的神经内分泌反应可能是恢复力的一个重要预测指标。基底外侧杏仁核（BLA）神经元和肾上腺糖皮质激素信号传导都是应激神经内分泌反应的组成部分。在本报告中，我们测试了应激激素反应的个体差异是否与BLA神经元树突复杂性的个体差异相关。我们报告了应激源后糖皮质激素反应的个体间变异性与BLA神经元可塑性之间存在正相关。这表明过去的应激经历是BLA神经元可塑性和一致的神经内分泌反应的重要塑造者。
