β-肾上腺素能阻滞剂的毒理学综述

A toxicological review of beta-adrenergic blockers.

作者信息

Jackson C D, Fishbein L

出版信息

Fundam Appl Toxicol. 1986 Apr;6(3):395-422. doi: 10.1016/0272-0590(86)90214-9.

Abstract

The use of various beta-adrenergic blockers has become extensive as they have been found to be efficacious in the treatment of a number of cardiovascular problems including cardiac arrhythmias, angina pectoris, and hypertension. The widespread and chronic use of these drugs has generated a concern for their potential chronic toxicity. Eighteen beta-adrenergic blockers have been reviewed and the available literature pertaining to their potential carcinogenicity, mutagenicity, and teratogenicity has been summarized and compared.

摘要

由于发现各种β-肾上腺素能阻滞剂在治疗包括心律失常、心绞痛和高血压在内的多种心血管问题方面有效，其使用已变得广泛。这些药物的广泛和长期使用引发了对其潜在慢性毒性的关注。已对18种β-肾上腺素能阻滞剂进行了综述，并对有关其潜在致癌性、致突变性和致畸性的现有文献进行了总结和比较。