Rosenthal J, Koehle W, Gruebel B, Fisher R
J Hypertens Suppl. 1986 Apr;4(1):S85-7.
The purpose of this study was to compare the effects of the serotonin antagonist ketanserin and the post-synaptic alpha-blocker prazosin on blood pressure in patients with essential hypertension. Both drugs lower blood pressure by a reduction in total peripheral vascular resistance and by reducing the pre- and afterload, apparently achieving these haemodynamic effects through different mechanisms. Ketanserin appears to have a greater effect on afterload. Six men and four women (mean age 47.2 years) with diastolic blood pressure greater than or equal to 100 mmHg were treated for 4 weeks with placebo and then randomized and treated for 8 weeks double-blind with either ketanserin or prazosin. A 4-week wash-out phase with placebo was then instituted followed by another 8 weeks of treatment in a crossover fashion with either ketanserin or prazosin. Blood pressure was measured on each occasion in the supine, sitting and standing positions. The results showed that both medications significantly lowered blood pressure (computed sitting values for all patients: ketanserin from 177/104 +/- 5/7 to 158/89 +/- 8/5 mmHg; prazosin from 176/103 +/- 11/8 to 156/88 +/- 6/4 mmHg). The data in this study show that ketanserin as an antihypertensive agent is as effective as prazosin, but in contrast requires no titration of dosage and better compliance can be expected with twice daily rather than three times daily dosing.
本研究的目的是比较5-羟色胺拮抗剂酮色林和突触后α阻滞剂哌唑嗪对原发性高血压患者血压的影响。两种药物均通过降低总外周血管阻力以及减轻前负荷和后负荷来降低血压，显然是通过不同机制实现这些血流动力学效应的。酮色林似乎对后负荷有更大的作用。6名男性和4名女性（平均年龄47.2岁），舒张压大于或等于100 mmHg，先用安慰剂治疗4周，然后随机分组，双盲接受酮色林或哌唑嗪治疗8周。接着是4周的安慰剂洗脱期，随后以交叉方式用酮色林或哌唑嗪再治疗8周。每次均在仰卧位、坐位和站立位测量血压。结果显示，两种药物均显著降低血压（所有患者坐位计算值：酮色林从177/104±5/7降至158/89±8/5 mmHg；哌唑嗪从176/103±11/8降至156/88±6/4 mmHg）。本研究数据表明，酮色林作为一种抗高血压药物与哌唑嗪效果相当，但与之不同的是，它无需调整剂量，每日两次给药比每日三次给药有望获得更好的依从性。
