Muralidharan Vetrivel, Nair Bijesh Ravindran, Patel Bimal, Rajshekhar Vedantam
Department of Neurological Sciences, Christian Medical College, Vellore, India.
Department of Pathology, Christian Medical College, Vellore, India.
World Neurosurg. 2017 Oct;106:1052.e5-1052.e11. doi: 10.1016/j.wneu.2017.07.008. Epub 2017 Jul 12.
Spinal cysticercosis has been reported in 0.7%-3.0% of patients with neurocysticercosis. Most patients with spinal cysticercosis have a coexisting intracranial disease. Most often this intracranial disease manifests as intradural extramedullary lesions involving thoracic and lumbar regions or intramedullary lesions. Intradural extramedullary primary spinal cysticercosis manifesting as cervical myelopathy is extremely rare and has not been reported to date.
A 56-year-old man from the northeastern part of India presented with progressive spastic quadriparesis. Magnetic resonance imaging showed a ventrally located intradural extramedullary multiloculated cyst with an enhancing wall in the upper cervical region. Enzyme-linked immunoelectrotransfer blot performed to detect cysticercal antibodies in serum was positive. The patient underwent total excision of the cysts, which were confirmed histologically to be cysticercal cysts. He was also treated with 2 weeks of albendazole therapy after surgery. He had recovered fully 1 year later.
Cysticercosis should be considered in the differential diagnosis in a patient with multiloculated cysts in the spinal subarachnoid space. Surgical exploration and excision of the cysts should be performed not only to establish a diagnosis but also to decompress the cord before medical therapy.
据报道,脊髓囊尾蚴病在神经囊尾蚴病患者中的发生率为0.7%-3.0%。大多数脊髓囊尾蚴病患者同时存在颅内疾病。这种颅内疾病最常见的表现为累及胸段和腰段的硬脊膜外髓外病变或髓内病变。表现为颈髓病的硬脊膜外髓外原发性脊髓囊尾蚴病极为罕见,迄今为止尚未见报道。
一名来自印度东北部的56岁男性,表现为进行性痉挛性四肢瘫。磁共振成像显示上颈段有一个位于腹侧的硬脊膜外髓外多房性囊肿,囊壁有强化。检测血清中囊尾蚴抗体的酶联免疫电转移印迹法结果为阳性。患者接受了囊肿全切术,术后病理证实为囊尾蚴囊肿。术后还给予了2周的阿苯达唑治疗。1年后患者完全康复。
对于脊髓蛛网膜下腔有多房性囊肿的患者,鉴别诊断时应考虑囊尾蚴病。应进行手术探查和囊肿切除,这不仅有助于明确诊断,还能在药物治疗前对脊髓进行减压。