Clemente Maria Grazia, Capobianco Giampiero, Galasso Paolo Mattia, Dessole Francesco, Virdis Giuseppe, Sanna Maria Grazia, Olzai Mauro Giorgio, Argiolas Lino, Dessole Salvatore, Antonucci Roberto
Pediatric Clinic, Department of Surgical, Microsurgical and Medical Sciences, University of Sassari, Sassari, Italy.
Gynecologic and Obstetric Clinic, Department of Surgical, Microsurgical and Medical Sciences, University of Sassari, Sassari, Italy.
Biomed Res Int. 2017;2017:9382083. doi: 10.1155/2017/9382083. Epub 2017 Jun 20.
Recent studies have shown that infants with intrauterine growth restriction (IUGR) undergo catch-up growth during infancy. The aim of our study was to evaluate the postnatal growth in a cohort of IUGR infants born in a tertiary-level Obstetric University Hospital of Northern Sardinia. An observational retrospective study was conducted on 12 IUGR (group A) and 12 control infants (group B) by measuring the anthropometric parameters of weight (), length () and head circumference (HC) from birth to the 3rd postnatal year. At birth, significant differences were found between group A and group B with regard to all the auxological parameters (, mean 1846.6 versus 3170.8 g, < 0.0001; HC, 30.1 versus 34.4 cm, < 0.0001; , mean 43.4 versus 49.4 cm, < 0.0001). During the 1st year, 8 of 12 (70%) IUGR infants exhibited a significant catch-up growth in the 3 anthropometric parameters and a regular growth until the 3rd year of follow-up. The majority but not all infants born with IUGR in our series showed significant postnatal catch-up growth essentially during the first 12 months of life. An improved knowledge of the causes of IUGR will help to develop measures for its prevention and individualized treatment.
近期研究表明，宫内生长受限（IUGR）婴儿在婴儿期会经历追赶生长。我们研究的目的是评估在撒丁岛北部一家三级产科大学医院出生的一组IUGR婴儿的出生后生长情况。通过测量从出生到出生后第3年的体重、身长和头围等人体测量参数，对12名IUGR婴儿（A组）和12名对照婴儿（B组）进行了一项观察性回顾性研究。出生时，A组和B组在所有体格学参数方面均存在显著差异（体重，平均1846.6对3170.8克，P<0.0001；头围，30.1对34.4厘米，P<0.0001；身长，平均43.4对49.4厘米，P<0.0001）。在第1年，12名IUGR婴儿中有8名（70%）在这3个体格测量参数方面表现出显著的追赶生长，并且在随访的第3年之前生长正常。在我们的系列研究中，大多数（但并非所有）出生时患有IUGR的婴儿在出生后的头12个月内基本上都表现出显著的追赶生长。更好地了解IUGR的病因将有助于制定其预防措施和个体化治疗方案。
