Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599.
Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, California 94720-3370.
Cold Spring Harb Perspect Biol. 2018 Jun 1;10(6):a029371. doi: 10.1101/cshperspect.a029371.
Dengue virus (DENV) is the most common arthropod-borne viral disease of humans. Although effective vaccines exist against other flaviviral diseases like yellow fever and Japanese encephalitis, dengue vaccine development is complicated by the presence of four virus serotypes and the possibility of partial immunity enhancing dengue disease severity. Several live attenuated dengue vaccines are being tested in human clinical trials. Initial results are mixed, with variable efficacy depending on DENV serotype and previous DENV exposure. Here, we highlight recent discoveries about the human antibody response to DENV and propose guidelines for advancing development of safe and effective dengue vaccines.
登革热病毒(DENV)是人类中最常见的虫媒病毒病。尽管针对其他黄病毒病(如黄热病和日本脑炎)已有有效的疫苗,但由于存在四种病毒血清型以及部分免疫可能增强登革热疾病严重程度,登革热疫苗的开发变得复杂。几种减毒活的登革热疫苗正在进行人体临床试验。初步结果喜忧参半,其有效性取决于 DENV 血清型和既往 DENV 暴露情况。在这里,我们重点介绍人类对 DENV 抗体反应的最新发现,并提出推进安全有效的登革热疫苗开发的指导方针。