吡非尼酮诱发的嗜酸性粒细胞性胸膜炎。
Pirfenidone-induced Eosinophilic Pleurisy.
作者信息
Hase Isano, Yamaguchi Bunpei, Takizawa Hidenori, Arakawa Hiroaki, Sakuma Hideo, Fujiu Koichi, Miyamoto Hideaki, Ishii Yoshiki
机构信息
Department of Respiratory Disease, Southern Tohoku General Hospital, Japan.
Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University, Japan.
出版信息
Intern Med. 2017;56(14):1863-1866. doi: 10.2169/internalmedicine.56.7738. Epub 2017 Jul 15.
The patient was a 69-year-old man with idiopathic pulmonary fibrosis who was taking pirfenidone. After 7 weeks of treatment, he suffered from left-sided eosinophilic pleurisy. Medical thoracoscopy was performed and the histopathological examination of the parietal pleura revealed the massive infiltration of eosinophils and lymphoid follicles. After stopping pirfenidone therapy, the patient's pleural effusion disappeared without additional treatment, and never recurred. This is the first case report of pirfenidone-induced pleurisy.
该患者为一名69岁患有特发性肺纤维化的男性，正在服用吡非尼酮。治疗7周后，他患上了左侧嗜酸性胸膜炎。进行了内科胸腔镜检查，壁层胸膜的组织病理学检查显示嗜酸性粒细胞和淋巴滤泡大量浸润。停用吡非尼酮治疗后，患者的胸腔积液未经额外治疗即消失，且未再复发。这是吡非尼酮诱发胸膜炎的首例病例报告。
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