低氧损伤在情绪障碍中的作用
Effect of Hypoxic Injury in Mood Disorder.
作者信息
Zhao Fenglian, Yang Junling, Cui Ranji
机构信息
Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun, Jilin 130041, China.
出版信息
Neural Plast. 2017;2017:6986983. doi: 10.1155/2017/6986983. Epub 2017 Jun 22.
Abstract
Hypoxemia is a common complication of the diseases associated with the central nervous system, and neurons are highly sensitive to the availability of oxygen. Neuroplasticity is an important property of the neural system controlling breathing, memory, and cognitive ability. However, the underlying mechanism has not yet been clearly elucidated. In recent years, several pieces of evidence have highlighted the effect of hypoxic injury on neuronal plasticity in the pathogenesis and treatment of mood disorder. Therefore, the present study reviewed the relevant articles regarding hypoxic injury and neuronal plasticity and discussed the pathological changes and physiological functions of neurons in hypoxemia in order to provide a translational perspective to the relevance of hypoxic injury and mood disorder.
摘要
低氧血症是中枢神经系统相关疾病的常见并发症，神经元对氧的供应高度敏感。神经可塑性是神经系统控制呼吸、记忆和认知能力的一项重要特性。然而，其潜在机制尚未完全阐明。近年来，一些证据突显了低氧损伤在情绪障碍发病机制和治疗中对神经元可塑性的影响。因此，本研究回顾了有关低氧损伤和神经元可塑性的相关文章，并探讨了低氧血症中神经元的病理变化和生理功能，以便为低氧损伤与情绪障碍之间的相关性提供一个转化医学视角。
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