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用激光和软管对抗真菌:巨大白色念珠菌感染的植入式心脏复律除颤器导线赘生物的处理,同时进行AngioVac抽吸和激光鞘导线拔除术

Fighting fungus with a laser and a hose: Management of a giant Candida albicans implantable cardioverter-defibrillator lead vegetation with simultaneous AngioVac aspiration and laser sheath lead extraction.

作者信息

Jones Brandon M, Wazni Oussama, Rehm Susan J, Shishehbor Mehdi H

机构信息

Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.

Department of Infectious Disease, Cleveland Clinic, Cleveland, Ohio.

出版信息

Catheter Cardiovasc Interv. 2018 Feb 1;91(2):318-321. doi: 10.1002/ccd.27153. Epub 2017 Jul 19.

Abstract

Infections involving internal cardiac devices can be very challenging to treat, and almost universally require complete device extraction for successful management. Of the pathogens that cause device-related endocarditis, fungi such as Candida albicans are notoriously difficult to manage because of their propensity to produce large vegetations and the need for long-term treatment with potentially toxic medications. Furthermore, individuals who develop fungal, device-associated endocarditis are typically among the most complex patients, with significant comorbidities that place them at high risk for open heart procedures such as surgical device extraction. We present a case of one such patient in whom treatment of Candida albicans device-related endocarditis was managed using AngioVac aspiration of a large right atrial vegetation with simultaneous laser sheath extraction of the implantable cardioverter-defibrillator lead.

摘要

涉及心脏内置装置的感染治疗极具挑战性,几乎无一例外都需要完整取出装置才能成功治愈。在引起装置相关性心内膜炎的病原体中,白色念珠菌等真菌因其易于形成大的赘生物以及需要使用具有潜在毒性的药物进行长期治疗而 notoriously 难以处理。此外,发生真菌性装置相关性心内膜炎的患者通常是最为复杂的患者群体,他们存在严重的合并症,这使得他们在进行诸如外科取出装置等心脏直视手术时面临高风险。我们报告了这样一位患者的病例,其白色念珠菌装置相关性心内膜炎的治疗采用了 AngioVac 抽吸右心房大赘生物并同时使用激光鞘管取出植入式心脏复律除颤器导线的方法。

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