透明细胞肾细胞癌条件下代谢途径基因表达水平的变化

Changes in levels of metabolic pathway gene expression under conditions of clear cell renal carcinoma.

作者信息

Bashmakov V Yu, Gorbacheva T M, Panevina A V, Solodskikh S A, Moshurov I P, Mikhaylov A A, Maslov A Yu, Popov V N

机构信息

Department of Genetics, Cytology, and Bioengineering, Voronezh State University, Voronezh, 394006, Russia.

Voronezh Regional Clinical Oncological Dispensary, Voronezh, 394036, Russia.

出版信息

Dokl Biochem Biophys. 2017 May;474(1):159-161. doi: 10.1134/S1607672917030024. Epub 2017 Jul 20.

DOI:10.1134/S1607672917030024

PMID:28726105

Abstract

A whole-transcriptome analysis of gene expression in six samples of clear cell renal cancer was performed. Using bioinformatics methods, we established a relationship between gene expression data and changes in activity of metabolic pathways: in this cancer type, the expression of genes involved in the metabolism of carbohydrates, lipids, and amino acids as well as in energy metabolism changed most significantly.

摘要

对六个透明细胞肾癌样本进行了基因表达的全转录组分析。利用生物信息学方法，我们建立了基因表达数据与代谢途径活性变化之间的关系：在这种癌症类型中，参与碳水化合物、脂质和氨基酸代谢以及能量代谢的基因表达变化最为显著。