Booth Adam L, Li Christine Q, Al-Dossari Ghannam Ayed, Stevenson Heather L
Department of Pathology, University of Texas Medical Branch , Galveston, Texas, USA.
BMJ Case Rep. 2017 Jul 19;2017:bcr-2017-220368. doi: 10.1136/bcr-2017-220368.
Dystrophic calcifications of the aortic valve may cause symptomatic aortic stenosis and account for a significant portion of patients who undergo elective valve replacement. Calcifications appearing grossly as a cloudy fluid surrounding the aortic valve leaflets are an uncommon finding. Normally, calcified aortic valves are characterised by large, nodular masses within the aortic cusps. We report a case of dystrophic calcifications on a stenotic aortic valve encountered intraoperatively, which was suggestive of infective endocarditis and abscess formation. Aortic valve leaflets and necrotic-appearing thymic lymph node tissue were submitted for histology and special stains. Cultures were negative and histology did not show evidence of infection. Tissue histology demonstrated extensive dystrophic calcifications, which were polarised to reveal abundant calcium oxalate crystals. The benign nature of this unique pathological finding ruled out any suspicion of infection, avoiding a prolonged course of intravenous antibiotics in this patient.
主动脉瓣营养不良性钙化可导致有症状的主动脉瓣狭窄,且在接受择期瓣膜置换的患者中占很大比例。肉眼可见主动脉瓣叶周围呈浑浊液体状的钙化是一种罕见的发现。通常,钙化的主动脉瓣的特征是主动脉瓣叶内有大的结节状肿块。我们报告了一例术中遇到的狭窄主动脉瓣上的营养不良性钙化病例,该病例提示感染性心内膜炎和脓肿形成。将主动脉瓣叶和外观呈坏死状的胸腺淋巴结组织送去做组织学检查和特殊染色。培养结果为阴性,组织学检查未显示感染迹象。组织学检查显示广泛的营养不良性钙化,经偏振光检查发现有大量草酸钙晶体。这一独特病理发现的良性性质排除了任何感染嫌疑,避免了该患者接受长时间的静脉抗生素治疗。