Cell Interactions and Cancer Group, MRC London Institute of Medical Sciences (LMS), Du Cane Road, London W12 0NN, United Kingdom; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom.
Cell Interactions and Cancer Group, MRC London Institute of Medical Sciences (LMS), Du Cane Road, London W12 0NN, United Kingdom; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, United Kingdom.
Curr Opin Neurobiol. 2017 Dec;47:8-15. doi: 10.1016/j.conb.2017.06.008. Epub 2017 Jul 18.
Glioblastoma (GBM) are aggressive and therapy-resistant brain tumours driven by glioma stem-like cells (GSCs). GSC behaviour is controlled by the microenvironment, or niche, in which the cells reside. It is well-established that the vasculature is a key component of the GSC niche, which drives maintenance in the tumour bulk and invasion at the margin. Emerging evidence now indicates that the specific properties of the vasculature within these two regions impose different functional states on resident GSCs, generating distinct subpopulations. Here, we review these recent findings, focusing on the mechanisms that underlie GSC/vascular communication. We further discuss how plasticity enables GSCs to respond to vascular changes by interconverting bidirectionally between states, and address the therapeutic implications of this dynamic response.
胶质母细胞瘤（GBM）是由神经胶质瘤干细胞（GSCs）驱动的侵袭性和耐药性脑肿瘤。GSC 的行为受到其所在的微环境或龛位的控制。众所周知，血管是 GSC 龛位的关键组成部分，它驱动肿瘤内部的维持和边缘的浸润。新出现的证据表明，这两个区域内血管的特定性质对驻留的 GSCs 施加了不同的功能状态，产生了不同的亚群。在这里，我们回顾这些最近的发现，重点讨论 GSC/血管通讯的机制。我们进一步讨论了可塑性如何使 GSCs 通过双向转换在状态之间反应，以及这种动态反应的治疗意义。
