Lee Ran, Shin Min-Ho, Kim Hee-Nam, Lee Young-Hoon, Choi Seong-Woo, Ahn Hye-Ran, Kweon Sun-Seog
Department of Preventive Medicine, Chonnam National University Medical School, 160 Baekseo-ro, Dong-gu, Gwangju, 501-746, Korea.
Center for Creative Biomedical Scientists, Chonnam National University, 160 Baekseo-ro, Dong-gu, Gwangju, Korea.
Int Urol Nephrol. 2017 Nov;49(11):2027-2033. doi: 10.1007/s11255-017-1662-3. Epub 2017 Jul 21.
Purpose This study investigated the cross-sectional association between chronic kidney disease (CKD) and plasma pentraxin 3 (PTX3) levels in a Korean population, in a community-based cohort study.
A total of 1816 (891 men, 925 women) subjects were randomly selected from the cohort of participants for the final analyses. Plasma PTX3 concentration was determined using enzyme-linked immunosorbent assays. The participants were divided into four quartiles according to the PTX3 levels. Multivariate logistic regression was performed to evaluate the association between plasma PTX3 level and CKD. Covariates inserted into the multivariate model included smoking status, systolic blood pressure, body mass index, waist circumference, high-density lipoprotein, low-density lipoprotein uric acid, white blood cell count, and carotid intima-media thickness.
Compared to the lowest PTX3 group (Q1), a significantly higher risk of CKD was found in the highest group (Q4), with an odds ratio of 1.58 and 95% confidence interval of 1.18-2.11 (P for trend <0.001).
This study showed that higher plasma PTX3 levels are significantly associated with CKD risk. The biological mechanism remains unclear; therefore, further molecular investigation of association between CKD and PTX3 is needed.
目的 在一项基于社区队列研究中，调查韩国人群中慢性肾脏病（CKD）与血浆五聚素3（PTX3）水平之间的横断面关联。
从参与者队列中随机选取共1816名受试者（891名男性，925名女性）进行最终分析。采用酶联免疫吸附测定法测定血浆PTX3浓度。根据PTX3水平将参与者分为四个四分位数组。进行多因素逻辑回归以评估血浆PTX3水平与CKD之间的关联。纳入多因素模型的协变量包括吸烟状况、收缩压、体重指数、腰围、高密度脂蛋白、低密度脂蛋白、尿酸、白细胞计数和颈动脉内膜中层厚度。
与PTX3最低组（Q1）相比，最高组（Q4）的CKD风险显著更高，优势比为1.58，95%置信区间为1.18 - 2.11（趋势P值<0.001）。
本研究表明，较高的血浆PTX3水平与CKD风险显著相关。生物学机制尚不清楚；因此，需要对CKD与PTX3之间的关联进行进一步的分子研究。
