Differential time-course of reaction time recovery depending on variations in the amplitude of a goal-directed movement after nigrostriatal lesion in monkeys.

Unilateral striatal dopamine depletion induced by 6-hydroxydopamine injections into the substantia nigra of behaving monkeys was found to increase the latency of a visually guided pointing movement performed by the contralateral forelimb. The time-course of recovery of the movement latency was faster in small displacements of the limb than in movements with larger amplitudes. The efficiency of putative compensatory mechanisms that may develop progressively in response to the striatal dopamine deficit depends on the amplitude of the movement to be initiated.