Pinilla M J, Tranquille C A, Blunden A S, Chang Y M, Parkin T D H, Murray R C
Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk, UK.
Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk, UK.
J Comp Pathol. 2017 Jul;157(1):1-10. doi: 10.1016/j.jcpa.2017.04.002.
A detailed histopathological study of the distal third metacarpal bone of Thoroughbred racehorses was undertaken to characterize lesions observed previously on magnetic resonance imaging (MRI). The bones were selected and grouped on the basis of MRI features. Representative sections in different planes were processed for histopathology. All lesions observed in the articular cartilage (AC) and subchondral bone (SCB) were recorded and graded with a scoring system, based partially on the Osteoarthritis Research Society International grading system. The scoring system included the severity of the lesion. Descriptive statistics and linear mixed effects models were performed. A positive correlation was observed between the severity of histopathological changes in the superficial and deeper osteochondral tissues, and between the number of race starts and AC score. Age was not correlated with AC or SCB score. A moderate variation in AC and SCB scores was observed between the groups; however, there were differences within individual bones. Bones with focal palmar necrosis (FPN) showed significant differences in the histological scoring of the AC compared with bones without FPN. Bones with incomplete fractures or larger areas of bone remodelling showed significant differences in SCB pathology when compared with bones with FPN. Haematoidin was detected in areas with excessive SCB and cancellous bone sclerosis and/or irregular bone density. This finding is suggestive of poor blood perfusion in these areas.
对纯种赛马的第三掌骨远端进行了详细的组织病理学研究，以描述先前在磁共振成像（MRI）上观察到的病变特征。根据MRI特征对骨骼进行选择和分组。对不同平面的代表性切片进行组织病理学处理。记录关节软骨（AC）和软骨下骨（SCB）中观察到的所有病变，并使用评分系统进行分级，该评分系统部分基于国际骨关节炎研究学会的分级系统。评分系统包括病变的严重程度。进行了描述性统计和线性混合效应模型分析。观察到浅层和深层骨软骨组织的组织病理学变化严重程度之间、以及比赛出场次数与AC评分之间存在正相关。年龄与AC或SCB评分无关。各分组之间观察到AC和SCB评分存在适度差异；然而，个体骨骼内部也存在差异。与无局灶性掌侧坏死（FPN）的骨骼相比，有FPN的骨骼在AC组织学评分上存在显著差异。与有FPN的骨骼相比，有不完全骨折或较大面积骨重塑的骨骼在SCB病理学上存在显著差异。在SCB过多、松质骨硬化和/或骨密度不规则的区域检测到含铁血黄素。这一发现提示这些区域的血液灌注不良。
