Abou Asa S
Laboratory of Veterinary Pathology, Faculty of Applied Biological Sciences, Gifu University, Gifu, Japan; Department of Veterinary Pathology, Faculty of Veterinary Medicine, Kafr ElSheikh University, Egypt.
J Comp Pathol. 2017 Jul;157(1):27-33. doi: 10.1016/j.jcpa.2017.05.001. Epub 2017 Jun 7.
MCAM/CD146 (melanoma cell adhesion molecule/CD146) is a transmembrane immunoglobulin superfamily cell adhesion molecule involved in transendothelial migration and signal transduction. It is expressed in melanoma, squamous cell carcinoma, prostatic, ovarian, cervical and endometrial cancers and promotes tumour growth, angiogenesis and metastasis. Melanoma is the most common malignant oral tumour of dogs and also arises in the skin, nail bed and footpad. The aim of this study was to investigate the immunohistochemical expression of MCAM/CD146 in 51 canine melanomas, including oral, cutaneous and ocular tumours. Seventeen of the 51 (33.3%) cases were negative, eight (15.7%) were weakly positive, seven (13.7%) were moderately positive and 19 (37.3%) were strongly positive. MCAM/CD146 was expressed by both oral and cutaneous melanomas; however, the intensity and the extent of the immunoreactivity was higher in oral (P = 0.009) than in cutaneous tumours (P = 0.058). Most ocular melanomas did not express MCAM/CD146 (P = 0.256). Expression of MCAM/CD146 by canine melanomas may suggest the molecule as a target for treatment, especially in oral melanomas.
MCAM/CD146（黑色素瘤细胞黏附分子/CD146）是一种跨膜免疫球蛋白超家族细胞黏附分子，参与跨内皮迁移和信号转导。它在黑色素瘤、鳞状细胞癌、前列腺癌、卵巢癌、宫颈癌和子宫内膜癌中表达，并促进肿瘤生长、血管生成和转移。黑色素瘤是犬类最常见的口腔恶性肿瘤，也可发生于皮肤、甲床和脚垫。本研究的目的是调查MCAM/CD146在51例犬黑色素瘤中的免疫组化表达情况，包括口腔、皮肤和眼部肿瘤。51例病例中有17例（33.3%）为阴性，8例（15.7%）为弱阳性，7例（13.7%）为中度阳性，19例（37.3%）为强阳性。口腔和皮肤黑色素瘤均表达MCAM/CD146；然而，口腔肿瘤中免疫反应的强度和范围高于皮肤肿瘤（口腔：P = 0.009；皮肤：P = 0.058）。大多数眼部黑色素瘤不表达MCAM/CD146（P = 0.256）。犬黑色素瘤表达MCAM/CD146可能提示该分子可作为治疗靶点，尤其是在口腔黑色素瘤中。
