HLA配型对中国小儿肾移植移植物存活的影响
Effect of HLA Matching on Pediatric Renal Transplant Graft Survival in China.
作者信息
Zhao H, Lai X, Lu J, Lin Y, Wang P, Zhu L, Wu L, Xiao Z, Wang Q, Tan J
机构信息
Department of Urology, Fuzhou General Hospital, Xiamen University, Fuzhou, China.
State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, China.
出版信息
Transplant Proc. 2017 Jul-Aug;49(6):1291-1293. doi: 10.1016/j.transproceed.2017.02.048.
INTRODUCTION
Kidney transplantation (KTX) has become one of the most effective therapies of choice for pediatric patients with end-stage renal disease (ESRD). The extent to which HLA mismatching influences graft survival following KTX has not been clarified.
PATIENTS AND METHODS
The effect of HLA amino acid residue matching on graft survival was assessed in 36 pediatric patients in whom complete donor-recipient HLA data were available. HLA-A, -B, -DR and HLA-A+B+DR loci residue mismatches were separately analyzed.
RESULTS
HLA-A, -B, -DR residue mismatches showed no significant statistical differences on kidney graft survival probability. When analyzing HLA-A+B+DR loci residue mismatches, the presence of 3 to 4 residue mismatches significantly increased the relative risk of graft rejection (P = .0292).
引言
肾移植（KTX）已成为终末期肾病（ESRD）儿科患者最有效的治疗选择之一。HLA配型不匹配对肾移植后移植物存活的影响程度尚未明确。
患者与方法
在36例可获得完整供体 - 受体HLA数据的儿科患者中，评估HLA氨基酸残基匹配对移植物存活的影响。分别分析了HLA - A、 - B、 - DR以及HLA - A + B + DR位点的残基错配情况。
结果
HLA - A、 - B、 - DR残基错配在肾移植存活概率上无显著统计学差异。在分析HLA - A + B + DR位点残基错配时，3至4个残基错配的存在显著增加了移植物排斥的相对风险（P = 0.0292）。
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