Levine L, Xiao D M, Fujiki H
Prostaglandins. 1986 Apr;31(4):669-81. doi: 10.1016/0090-6980(86)90173-5.
In the presence of 12-O-tetradecanoylphorbol-13-acetate (TPA) or the non-TPA-type tumor promoter, palytoxin, recombinant human insulin growth factor-I (IGF-I) and insulin synergistically stimulate prostaglandin production in rat liver cells (the C-9 cell line). Combinations of palytoxin or TPA with recombinant human IGF-I or insulin also synergistically stimulate deesterification of cellular lipids in C-9 cells prelabelled with [3H]arachidonic acid. With both types of stimulations, prostaglandin production or deesterification, the synergistic response of the IGF-I and insulin is greater with palytoxin than with TPA. Production of prostaglandin E2 and F2 alpha by squirrel monkey smooth muscle cells incubated in the presence of TPA and insulin also is greater than the sum of the two effects taken independently.
在存在12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯（TPA）或非TPA型肿瘤启动子（刺尾鱼毒素）的情况下，重组人胰岛素生长因子 - I（IGF - I）和胰岛素协同刺激大鼠肝细胞（C - 9细胞系）中前列腺素的产生。刺尾鱼毒素或TPA与重组人IGF - I或胰岛素的组合也协同刺激用[3H]花生四烯酸预标记的C - 9细胞中细胞脂质的去酯化。对于前列腺素产生或去酯化这两种类型的刺激，IGF - I和胰岛素的协同反应在刺尾鱼毒素存在时比在TPA存在时更大。在TPA和胰岛素存在下孵育的松鼠猴平滑肌细胞产生的前列腺素E2和F2α也大于单独考虑这两种效应时的总和。
