Marois G, Henrotte J G, Elie C, Franck G
Ann Endocrinol (Paris). 1985;46(6):399-405.
The Ca2+ dependent release of both dopamine (DA) and prolactin (Prl) is modified by stress. Plasma magnesium (Mg) concentrations are also modified. Therefore, we have investigated on plasma (P) Mg and Prl, the immediate and delayed effects of one, five or six daily injections of bromocriptine (BMC, 200 micrograms/100 g) and thioproperazine (100 micrograms/100 g), respectively agonist and antagonist of pituitary DA receptors. One hour after injection of either drugs, an increased P Mg is observed while P Prl is increased or decreased. No correlation is, thus, established between P Prl and P Mg changes. The P Mg increase is long-lasting after BMC, transitory after thioproperazine as shown by determinations performed 23 h after the 5th injection. When the two drugs are simultaneously given, no important modifications of P Mg are observed. The mechanisms and consequences of this P Mg increase are discussed. During stress, the hypermagnesemia could modulate the Prl secretion and action, hindering its secretion on one hand, and potentiating its action on target-organs, on the other hand.
多巴胺（DA）和催乳素（Prl）的钙离子依赖性释放会因应激而改变。血浆镁（Mg）浓度也会发生变化。因此，我们研究了分别作为垂体DA受体激动剂和拮抗剂的溴隐亭（BMC，200微克/100克）和硫代丙嗪（100微克/100克）每日注射一次、五次或六次对血浆（P）镁和催乳素的即时和延迟影响。注射任何一种药物1小时后，观察到血浆镁升高，而血浆催乳素升高或降低。因此，血浆催乳素和血浆镁变化之间未建立相关性。如在第5次注射后23小时所做的测定所示，溴隐亭注射后血浆镁升高持续时间长，硫代丙嗪注射后则是短暂的。当同时给予这两种药物时，未观察到血浆镁有重要变化。本文讨论了血浆镁升高的机制和后果。在应激期间，高镁血症可能调节催乳素的分泌和作用，一方面阻碍其分泌，另一方面增强其对靶器官的作用。
