[苯二氮䓬类药物对大鼠脑组织中AMP脱氨酶和腺苷脱氨酶体内活性的影响]
[Effect of benzodiazepines on the activity of AMP deaminase and adenosine deaminase in rat brain tissue in vivo].
作者信息
Korotkina R N, Papin A A, Karelin A A
出版信息
Biull Eksp Biol Med. 1986 Jul;102(7):41-4.
PMID:2873849
Abstract
Phenazepam (5 mg/200 g) and seduxen (3 mg/200 g) injected intraperitoneally to 184 rats altered AMP-deaminase and adenosine deaminase brain activity. Seduxen was observed to increase AMP-deaminase and adenosine deaminase activity by 89.1% and 32.4%, respectively an hour after the injection. Phenazepam increased the activity of the enzymes by 35.5% and 38.5%, respectively two hours after the injection. The effect is suggested to be due to de novo benzodiazepine-induced enzyme synthesis.
摘要
将非那西泮（5毫克/200克）和速可眠（3毫克/200克）腹腔注射给184只大鼠后，改变了大鼠大脑中AMP脱氨酶和腺苷脱氨酶的活性。观察到，注射速可眠1小时后，AMP脱氨酶和腺苷脱氨酶的活性分别增加了89.1%和32.4%。注射非那西泮2小时后，这两种酶的活性分别增加了35.5%和38.5%。这种作用被认为是由于苯二氮卓类药物诱导的从头酶合成。
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