Edwards C A, Read N W
Dig Dis Sci. 1986 Aug;31(8):817-21. doi: 10.1007/BF01296049.
The effects of a new antidiarrheal agent, lidamidine (10 mg per os) and an identical placebo on jejunal fluid and electrolyte transport in vivo were investigated in five normal volunteers during steady-state perfusion of a 25-cm length of jejunum with a plasma-like solution. Studies were carried out under basal conditions and during secretion stimulated by incorporation of prostaglandin E2 (5 X 10(-6) M) in the infusate. Lidamidine had no significant effect on jejunal fluid transport under basal conditions but reduced secretion induced by prostaglandin E2 (P less than 0.05).
在五名正常志愿者体内,当用类似血浆的溶液对25厘米长的空肠进行稳态灌注时,研究了一种新型止泻剂利达脒(口服10毫克)和一种相同的安慰剂对空肠液体和电解质转运的影响。研究在基础条件下以及在灌注液中加入前列腺素E2(5×10⁻⁶ M)刺激分泌的过程中进行。利达脒在基础条件下对空肠液体转运无显著影响,但可减少前列腺素E2诱导的分泌(P<0.05)。