超越发现空白：抗菌化合物的新靶点
Beyond the Discovery Void: New targets for antibacterial compounds.
作者信息
Broughton Claire E, Van Den Berg Hugo A, Wemyss Alan M, Roper David I, Rodger Alison
出版信息
Sci Prog. 2016 Jun 1;99(2):153-182. doi: 10.3184/003685016X14616130512308.
Abstract
Antibiotics save many lives, but their efficacy is under threat: overprescription, population growth, and global travel all contribute to the rapid origination and spread of resistant strains. Exacerbating this threat is the fact that no new major classes of antibiotics have been discovered in the last 30 years: this is the "discovery void." We discuss the traditional molecular targets of antibiotics as well as putative novel targets.
摘要
抗生素挽救了许多生命，但其效力正受到威胁：过度处方、人口增长和全球旅行都促使耐药菌株迅速产生和传播。使这一威胁加剧的是，在过去30年里未发现任何新的主要抗生素类别：这就是“发现空白”。我们讨论了抗生素的传统分子靶点以及假定的新靶点。
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