自主神经系统在间歇性低压低氧抗心律失常作用中的参与

Involvement of Autonomic Nervous System in Antiarrhythmic Effect of Intermittent Hypobaric Hypoxia.

作者信息

Naryzhnaya N V, Mukhamedzyanov A V, Lasukova T V, Maslov L N

机构信息

Research Institute of Cardiology, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.

Department of Medical and Biological Sciences, Tomsk State Pedagogical University, Tomsk, Russia.

出版信息

Bull Exp Biol Med. 2017 Jul;163(3):299-301. doi: 10.1007/s10517-017-3789-8. Epub 2017 Jul 25.

DOI:10.1007/s10517-017-3789-8

PMID:28744643

Abstract

We studied the involvement of the autonomic nervous system in the antiarrhythmic effect of intermittent hypobaric hypoxia modeled by daily placing the rats into an altitude chamber at 405 mm Hg (5000 m above sea level). The antiarrhythmic effect of hypoxia was observed on the model of acute coronary occlusion/reperfusion in vivo, but not during simulation of total ischemia/reperfusion of the isolated myocardium. Intravenous injection of ganglionic blocker hexamethonium (30 mg/kg) 15 min prior to in vivo coronary occlusion modeling abolished the antiarrhythmic effect of intermittent hypobaric hypoxia, which suggests that this effect is mediated via activation of the autonomic nervous system.

摘要

我们通过每天将大鼠置于海拔5000米（相当于405毫米汞柱）的低压舱内来模拟间歇性低压缺氧，研究了自主神经系统在其抗心律失常作用中的参与情况。在体内急性冠状动脉闭塞/再灌注模型中观察到了缺氧的抗心律失常作用，但在离体心肌全缺血/再灌注模拟过程中未观察到。在体内冠状动脉闭塞建模前15分钟静脉注射神经节阻滞剂六甲铵（30毫克/千克）消除了间歇性低压缺氧的抗心律失常作用，这表明该作用是通过自主神经系统的激活介导的。