脑源性神经营养因子/酪氨酸激酶受体B通路在视觉系统中的作用：对青光眼的治疗意义
Role of BDNF/TrkB pathway in the visual system: Therapeutic implications for glaucoma.
作者信息
Mysona B A, Zhao J, Bollinger K E
机构信息
Augusta University Department of Cellular Biology and Anatomy, James and Jean Culver Vision Discovery Institute. Address: Augusta University Department of Cellular Biology and Anatomy, Health Sciences Campus, 1120 15th Street, Augusta, GA 30912, USA,.
Medical College of Georgia, Department of Ophthalmology at Augusta University, James and Jean Culver Vision Discovery Institute. Address: Medical College of Georgia, Department of Ophthalmology at Augusta University, 1120 15th Street, Augusta, GA 30912, USA,.
出版信息
Expert Rev Ophthalmol. 2017;12(1):69-81. doi: 10.1080/17469899.2017.1259566. Epub 2016 Nov 23.
INTRODUCTION
Neuroprotective therapeutics are needed to treat glaucoma, an optic neuropathy that results in death of retinal ganglion cells (RGCs).
AREAS COVERED
The BDNF/TrkB pathway is important for RGC survival. Temporal and spatial alterations in the BDNF/TrkB pathway occur in development and in response to acute optic nerve injury and to glaucoma. In animal models, BDNF supplementation is successful at slowing RGC death after acute optic nerve injury and in glaucoma, however, the BDNF/TrkB signaling is not the only pathway supporting long term RGC survival.
EXPERT COMMENTARY
Much remains to be discovered about the interaction between retrograde, anterograde, and retinal BDNF/TrkB signaling pathways in both neurons and glia. An ideal therapeutic agent for glaucoma likely has several modes of action that target multiple mechanisms of neurodegeneration including the BDNF/TrkB pathway.
引言
青光眼是一种导致视网膜神经节细胞（RGCs）死亡的视神经病变，需要神经保护疗法来治疗。
涵盖领域
BDNF/TrkB通路对RGC存活至关重要。BDNF/TrkB通路在发育过程中以及对急性视神经损伤和青光眼的反应中会发生时空改变。在动物模型中，补充BDNF成功减缓了急性视神经损伤后和青光眼患者RGC的死亡，然而，BDNF/TrkB信号传导并非支持RGC长期存活的唯一途径。
专家评论
关于神经元和神经胶质细胞中逆行、顺行和视网膜BDNF/TrkB信号通路之间的相互作用，仍有许多有待发现之处。理想的青光眼治疗药物可能具有多种作用模式，可针对包括BDNF/TrkB通路在内的多种神经退行性变机制。
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