泛醌X-泛醌D系统：异戊烯基化黄素（prFMN）的生物合成与利用
The UbiX-UbiD system: The biosynthesis and use of prenylated flavin (prFMN).
作者信息
Marshall Stephen A, Payne Karl A P, Leys David
机构信息
Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.
Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.
出版信息
Arch Biochem Biophys. 2017 Oct 15;632:209-221. doi: 10.1016/j.abb.2017.07.014. Epub 2017 Jul 25.
The UbiX-UbiD system consists of the flavin prenyltransferase UbiX that produces prenylated FMN that serves as the cofactor for the (de)carboxylase UbiD. Recent developments have provided structural insights into the mechanism of both enzymes, detailing unusual chemistry in each case. The proposed reversible 1,3-dipolar cycloaddition between the cofactor and substrate serves as a model to explain many of the key UbiD family features. However, considerable variation exists in the many branches of the UbiD family tree.
UbiX-UbiD系统由黄素异戊烯基转移酶UbiX组成，该酶产生异戊烯基化的FMN，作为（脱）羧酶UbiD的辅因子。最近的研究进展为这两种酶的作用机制提供了结构上的见解，详细阐述了每种情况下不同寻常的化学过程。辅因子与底物之间拟议的可逆1,3-偶极环加成反应可作为一个模型，用以解释UbiD家族的许多关键特征。然而，UbiD家族树的众多分支中存在相当大的差异。
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