Souza Alexandre Wagner Silva de, Calich Ana Luisa, Mariz Henrique de Ataíde, Ochtrop Manuella Lima Gomes, Bacchiega Ana Beatriz Santos, Ferreira Gilda Aparecida, Rêgo Jozelia, Perez Mariana Ortega, Pereira Rosa Maria Rodrigues, Bernardo Wanderley Marques, Levy Roger Abramino
Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM), Disciplina de Reumatologia, São Paulo, SP, Brazil.
Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM), Disciplina de Reumatologia, São Paulo, SP, Brazil.
Rev Bras Reumatol Engl Ed. 2017;57 Suppl 2:484-496. doi: 10.1016/j.rbre.2017.06.003. Epub 2017 Jul 25.
The purpose of these recommendations is to guide the appropriate induction treatment of antineutrophil cytoplasmic antibody-associated vasculitis (AAV) patients with active disease. The recommendations proposed by the Vasculopathies Committee of the Brazilian Society Rheumatology for induction therapy of AAV, including granulomatosis with polyangiitis, microscopic polyangiitis and renal-limited vasculitis, were based on systematic literature review and expert opinion. Literature review was performed using Medline (PubMed), EMBASE and Cochrane database to retrieve articles until October 2016. PRISMA guidelines were used for the systematic review and articles were assessed according to the Oxford levels of evidence. Sixteen recommendations were made regarding different aspects of induction therapy for AAV. The purpose of these recommendations is to serve as a guide for therapeutic decisions by health care professionals in the management of AAV patients presenting active disease.
这些建议的目的是指导抗中性粒细胞胞浆抗体相关性血管炎（AAV）活动期患者进行适当的诱导治疗。巴西风湿病学会血管病委员会针对AAV诱导治疗提出的建议，包括肉芽肿性多血管炎、显微镜下多血管炎和局限于肾脏的血管炎，是基于系统的文献综述和专家意见。使用Medline（PubMed）、EMBASE和Cochrane数据库进行文献综述，以检索截至2016年10月的文章。PRISMA指南用于系统评价，文章根据牛津证据水平进行评估。针对AAV诱导治疗的不同方面提出了16条建议。这些建议的目的是为医疗保健专业人员在管理患有活动期疾病的AAV患者时的治疗决策提供指导。
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