Psycho-Oncology Co-operative Research Group, School of Psychology, University of Sydney, Sydney, New South Wales, Australia.
Behavioural Sciences Unit, Kids Cancer Centre, Sydney Children's Hospital, School of Women's and Children's Health, UNSW Sydney, Kensington, New South Wales, Australia.
Psychooncology. 2018 Feb;27(2):492-499. doi: 10.1002/pon.4516. Epub 2017 Aug 18.
Fear of cancer recurrence (FCR) is a common concern among cancer survivors. Identifying survivors with clinically significant FCR requires validated screening measures and clinical cut-offs. We evaluated the Fear of Cancer Recurrence Inventory-Short Form (FCRI-SF) clinical cut-off in 2 samples.
Level of FCR in study 1 participants (from an Australian randomized controlled trial: ConquerFear) was compared with FCRI-SF scores. Based on a biopsychosocial interview, clinicians rated participants as having nonclinical, subclinical, or clinical FCR. Study 2 participants (from a Canadian FCRI-English validation study) were classified as having clinical or nonclinical FCR by using the semistructured clinical interview for FCR (SIFCR). Receiver operating characteristic analyses evaluated the screening ability of the FCRI-SF against clinician ratings (study 1) and the SIFCR (study 2).
In study 1, 167 cancer survivors (mean age: 53 years, SD = 10.1) participated. Clinicians rated 43% as having clinical FCR. In study 2, 40 cancer survivors (mean age: 68 years, SD = 7.0) participated; 25% met criteria for clinical FCR according to the SIFCR. For both studies 1 and 2, receiver operating characteristic analyses suggested a cut-off ≥22 on the FCRI-SF identified cancer survivors with clinical levels of FCR with adequate sensitivity and specificity.
Establishing clinical cut-offs on FCR screening measures is crucial to tailoring individual care and conducting rigorous research. Our results suggest using a higher cut-off on the FCRI-SF than previously reported to identify clinically significant FCR. Continued evaluation and validation of the FCRI-SF cut-off is required across diverse cancer populations.
癌症复发恐惧(FCR)是癌症幸存者的常见问题。识别具有临床显著 FCR 的幸存者需要经过验证的筛查措施和临床临界值。我们在 2 个样本中评估了简短版癌症复发恐惧量表(FCRI-SF)的临床临界值。
在研究 1 参与者(来自澳大利亚的一项随机对照试验:克服恐惧)中比较了 FCR 水平与 FCRI-SF 评分。基于生物心理社会访谈,临床医生将参与者评定为无临床、亚临床或临床 FCR。在研究 2 中,加拿大 FCRI-英语验证研究的参与者使用 FCR 半结构化临床访谈(SIFCR)被分类为有临床或无临床 FCR。接受者操作特征分析评估了 FCRI-SF 对临床医生评分(研究 1)和 SIFCR(研究 2)的筛查能力。
在研究 1 中,167 名癌症幸存者(平均年龄:53 岁,标准差=10.1)参与了研究。临床医生评定 43%的参与者为临床 FCR。在研究 2 中,40 名癌症幸存者(平均年龄:68 岁,标准差=7.0)参与了研究;根据 SIFCR,25%的参与者符合临床 FCR 的标准。对于研究 1 和 2,接受者操作特征分析表明,FCRI-SF 得分≥22 可以识别出具有临床 FCR 水平的癌症幸存者,具有足够的敏感性和特异性。
确定 FCR 筛查措施的临床临界值对于定制个体化护理和开展严格的研究至关重要。我们的研究结果表明,使用 FCRI-SF 的较高临界值来识别具有临床意义的 FCR。需要在不同的癌症人群中进一步评估和验证 FCRI-SF 临界值。