与骨骼相关的生化检测。

Biochemical Testing Relevant to Bone.

机构信息

Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, E-18A, 200 1st Street Southwest, Rochester, MN 55905, USA.

出版信息

Endocrinol Metab Clin North Am. 2017 Sep;46(3):649-667. doi: 10.1016/j.ecl.2017.04.003. Epub 2017 Jun 20.

DOI:10.1016/j.ecl.2017.04.003

PMID:28760231

Abstract

Laboratory biochemical testing is critical to the clinical understanding of bone disorders. Patients with skeletal diseases have underlying themes in their pathophysiology that would be impossible to detect without biochemical assessment of serum and urine minerals, vitamin D, parathyroid hormone, parathyroid hormone-related peptide, and bone turnover markers. Bone disorders are caused by abnormalities in signaling pathways that affect bone formation and resorption. Therapies for common bone diseases were developed in direct response to underlying biochemical abnormalities.

摘要

实验室生化检测对骨骼疾病的临床诊断至关重要。如果不通过血清和尿液矿物质、维生素 D、甲状旁腺激素、甲状旁腺激素相关肽和骨转换标志物的生化评估，就无法检测到骨骼疾病患者的病理生理学中的潜在主题。骨骼疾病是由影响骨形成和吸收的信号通路异常引起的。针对常见骨骼疾病的治疗方法是直接针对潜在的生化异常而开发的。