Attia Ali Kamal, Saad Ahmed Sayed, Alaraki Manal Sami, Elzanfaly Eman Saad
National Organization for Drug Control and Research, P.O. Box 29, Cairo, Egypt.
Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, Egypt.
Adv Pharm Bull. 2017 Jun;7(2):329-334. doi: 10.15171/apb.2017.039. Epub 2017 Jun 30.
Thermal analysis techniques have been applied to study the thermal behavior of fenbendazole (Fen) and rafoxanide (Raf). Semi-empirical molecular orbital calculations were used to confirm these results. Thermogravimetric analysis, derivative thermogravimetry, differential thermal analysis and differential scanning calorimetry were used to determine the thermal behavior and purity of the drugs under investigation. Thermal behavior of Fen and Raf were augmented using semi-empirical molecular orbital calculations. The purity values were found to be 99.17% and 99.60% for Fen and Raf, respectively. Thermal analysis techniques gave satisfactory results to obtain quality control parameters such as melting point and degree of purity at low cost, furthermore, its simplicity and sensitivity justifies its application in quality control laboratories.
热分析技术已被应用于研究芬苯达唑（Fen）和雷复尼特（Raf）的热行为。采用半经验分子轨道计算来证实这些结果。使用热重分析、微商热重分析、差示热分析和差示扫描量热法来确定所研究药物的热行为和纯度。通过半经验分子轨道计算增强了芬苯达唑和雷复尼特的热行为。发现芬苯达唑和雷复尼特的纯度值分别为99.17%和99.60%。热分析技术能以低成本获得熔点和纯度等质量控制参数，给出令人满意的结果，此外，其简单性和灵敏度证明了它在质量控制实验室中的应用价值。
