Zhu Qicui, Xu Jianhua, Wang Kang, Cai Jingyu, Wu Juan, Ren Jiale, Zheng Shuang, Ding Changhai
Department of Rheumatology and Immunology, Arthritis Research Institute, the First Affiliated Hospital of Anhui Medical University, Hefei, China.
Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.
Int J Rheum Dis. 2018 Jun;21(6):1202-1210. doi: 10.1111/1756-185X.13148. Epub 2017 Aug 1.
The relationship between bone mineral density (BMD) and osteoarthritis (OA) remains controversial. This study aimed to explore the cross-sectional associations between BMD at the total body, hip and spine and joint structural abnormalities including cartilage defects and bone marrow lesions (BMLs) in patients with knee OA.
One hundred and eight-five subjects with symptomatic knee OA were included in this study. T2-weighted fast spin echo magnetic resonance imaging was used to assess knee cartilage defects and BMLs. Total body, hip and spine BMD were measured using dual-energy X-ray absorptiometry.
After adjustment for potential confounders, total hip BMD was negatively associated with medial tibial cartilage defects, lateral femoral cartilage defects, medial tibial BMLs and lateral tibial BMLs. Spine and total body BMD were negatively associated with lateral femoral cartilage defects, but not with BMLs.
We concluded that BMD particularly at the hip was negatively associated with knee cartilage defects and BMLs.
骨矿物质密度（BMD）与骨关节炎（OA）之间的关系仍存在争议。本研究旨在探讨膝关节OA患者全身、髋部和脊柱的骨密度与关节结构异常（包括软骨缺损和骨髓病变（BMLs））之间的横断面关联。
本研究纳入了185例有症状的膝关节OA患者。采用T2加权快速自旋回波磁共振成像评估膝关节软骨缺损和BMLs。使用双能X线吸收法测量全身、髋部和脊柱的骨密度。
在对潜在混杂因素进行校正后，全髋骨密度与胫骨内侧软骨缺损、股骨外侧软骨缺损、胫骨内侧BMLs和胫骨外侧BMLs呈负相关。脊柱和全身骨密度与股骨外侧软骨缺损呈负相关，但与BMLs无关。
我们得出结论，尤其是髋部的骨密度与膝关节软骨缺损和BMLs呈负相关。
