肛管鳞状细胞癌的初始管理：一家社区医院30年的经验

Primary Management of Squamous Cell Carcinoma of the Anal Canal: A 30-year Community Hospital Experience.

作者信息

Agarwal Mohit S, Jones Daniel A, Mendenhall Charles M, Morris Christopher G, Johns Andrew, McAfee William J, Mendenhall William M

机构信息

a Department of Radiation Oncology , Phoebe Putney Memorial Hospital , Albany , Georgia , USA.

b Department of Radiation Oncology , University of Florida College of Medicine , Gainesville , Florida , USA.

出版信息

Cancer Invest. 2017 Sep 14;35(8):547-551. doi: 10.1080/07357907.2017.1344699. Epub 2017 Aug 1.

DOI:10.1080/07357907.2017.1344699

PMID:28762852

Abstract

We reviewed outcomes of 41 patients treated with curative-intent radiotherapy for anal canal carcinoma at a community hospital between 1985 and 2015. Twenty-six (63%) presented with stage I or II disease while 15 (37%) had stage III. Thirty-seven received definitive chemoradiation and 4 radiotherapy alone. Thirteen (31.7%) received ≤59.4Gy. Thirty-two (78%) were treated with 3-dimensional conformal radiotherapy while 9 (22%) received intensity-modulated radiotherapy. At 5 years, local control, regional control, freedom from distant metastasis, cause-specific survival, and overall survival were 80%, 98%, 88%, 77%, and 51%. Of those who received >59.4Gy, local control and overall survival were not improved.

摘要

我们回顾了1985年至2015年间在一家社区医院接受根治性放疗的41例肛管癌患者的治疗结果。26例（63%）为I期或II期疾病，15例（37%）为III期。37例接受了根治性放化疗，4例仅接受了放疗。13例（31.7%）接受的剂量≤59.4Gy。32例（78%）接受了三维适形放疗，9例（22%）接受了调强放疗。5年时，局部控制率、区域控制率、无远处转移生存率、病因特异性生存率和总生存率分别为80%、98%、88%、77%和51%。接受剂量>59.4Gy的患者，局部控制率和总生存率并未得到改善。