National Center for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, Bronx, New York.
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Ann N Y Acad Sci. 2017 Aug;1402(1):10-17. doi: 10.1111/nyas.13411. Epub 2017 Aug 1.
Cyclical, mechanical loading of bone by skeletal muscle is widely recognized as a critical determinant of bone structure and mass. A growing body of evidence indicates that substances released from skeletal muscle into the bloodstream also regulate bone mass and metabolism. In this commentary, we discuss the status of research in the area of humoral regulation of bone mass by the skeletal muscle secretome, with an emphasis on the roles of myostatin, irisin, interleukin-6, and exosomes. The interplay between muscle, bone, and other modulators of bone mass, including circadian rhythm and sympathetic tone, is also discussed.
骨骼肌肉对骨骼的周期性、机械性加载被广泛认为是骨骼结构和质量的关键决定因素。越来越多的证据表明，骨骼肌肉释放到血液中的物质也调节骨量和代谢。在这篇评论中，我们讨论了骨骼肌肉分泌组对骨量的体液调节作用的研究现状，重点介绍了肌肉生长抑制素、鸢尾素、白细胞介素-6 和外泌体的作用。还讨论了肌肉、骨骼和其他骨量调节剂（包括昼夜节律和交感神经张力）之间的相互作用。
