Gubskiĭ Iu I, Zadorina O V, Tkachuk V V, Igrunov L P
Vopr Med Khim. 1986 Jul-Aug;32(4):80-5.
Compartmentalization of Ca2+ was studied in homogenates and subcellular fractions (nuclei, mitochondria, microsomes and cytosol fraction) of rat liver tissue under conditions of chemical lesion of hepatocyte membranes caused by CCl4. The studies were carried out within 2, 24, 48, 96 and 168 hrs after the CCl4 administration. The chemical lesion of hepatocyte membranes led to considerable increase in Ca2+ concentration in the subcellular fractions studied, especially in cytosol fraction, where it reached about 424% as compared with the control level. The drastic increase of calcium concentration in cytosol appears to be due to disturbance of both Ca2+ elimination through plasmatic membrane and its mitochondrial sequestration.
在四氯化碳导致肝细胞膜化学损伤的条件下，对大鼠肝组织匀浆及亚细胞组分（细胞核、线粒体、微粒体和胞质溶胶组分）中的钙离子区室化进行了研究。研究在四氯化碳给药后的2、24、48、96和168小时内进行。肝细胞膜的化学损伤导致所研究的亚细胞组分中钙离子浓度显著增加，尤其是在胞质溶胶组分中，与对照水平相比，其钙离子浓度达到约424%。胞质溶胶中钙浓度的急剧增加似乎是由于通过质膜的钙离子清除及其线粒体隔离均受到干扰所致。
