苝染料的腔内折叠可形成与葫芦[8]脲的高亲和力复合物。
Intracavity folding of a perylene dye affords a high-affinity complex with cucurbit[8]uril.
作者信息
Aryal Gyan H, Assaf Khaleel I, Hunter Kenneth W, Nau Werner M, Huang Liming
机构信息
A Department of Microbiology and Immunology, School of Medicine, University of Nevada, Reno, NV 89557, USA.
出版信息
Chem Commun (Camb). 2017 Aug 15;53(66):9242-9245. doi: 10.1039/c7cc03483k.
PMID:28766596
Abstract
A fluorescent perylene dye with two aromatic units was designed for binding to cucurbit[8]uril. The binding affinity of the complexes increased about 3 orders of magnitude compared to the dye without a secondary aromatic unit. The high affinity allows the complexes to act as fluorescent probes for detection of strong binding guests with nanomolar sensitivity.
摘要
设计了一种带有两个芳香单元的荧光苝染料，用于与葫芦[8]脲结合。与没有二级芳香单元的染料相比，该配合物的结合亲和力提高了约3个数量级。这种高亲和力使该配合物能够作为荧光探针，以纳摩尔灵敏度检测强结合客体。
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