Schröder H C, Becker R, Bachmann M, Gramzow M, Seve A P, Monsigny M, Müller W E
Biochim Biophys Acta. 1986 Nov 13;868(2-3):108-18. doi: 10.1016/0167-4781(86)90013-8.
Nucleocytoplasmic transport of rat liver mRNA is thought to be regulated by a nucleoside triphosphatase whose activity in the intact nuclear envelope is stimulated by the 3'poly(A) tail of poly(A)+ mRNA. In contrast to the liver mRNA, the mRNA from rat brain contains a great population of poly(A)- mRNA's that does not appear until after birth. Measurements of the nuclear-envelope-associated enzyme activities involved in mRNA transport, and their dependence on endogenous (isolated cytoplasmic mRNA-transport-stimulating proteins) and exogenous (poly(A), lectins, and neoglycoproteins) factors during prenatal and postnatal rat brain and liver development, revealed marked organ-dependent differences paralleling the appearance of the poly(A)- mRNA unique in the brain.
大鼠肝脏mRNA的核质运输被认为受一种核苷三磷酸酶调控，该酶在完整核膜中的活性受到多聚腺苷酸（poly(A)）+ mRNA的3'多聚腺苷酸尾的刺激。与肝脏mRNA不同，大鼠脑mRNA包含大量直到出生后才出现的无多聚腺苷酸（poly(A)）- mRNA。在产前和产后大鼠脑和肝脏发育过程中，对参与mRNA运输的核膜相关酶活性及其对内源性（分离的细胞质mRNA运输刺激蛋白）和外源性（多聚腺苷酸、凝集素和新糖蛋白）因素的依赖性进行测量，结果显示出与脑中独特的无多聚腺苷酸（poly(A)）- mRNA出现情况平行的明显器官依赖性差异。
