Williams Christopher S, Spitz Mark C, Foley John F, Weaver Lindell K, Lindblad Anne S, Wierzbicki Michael R
Lovelace Biomedical Research, Albuquerque, New Mexico U.S.
CHMG Neurosciences, University of Colorado, Colorado Springs, Colorado U.S.
Undersea Hyperb Med. 2016 Aug-Sept;43(5):521-530.
The Brain Injury and Mechanisms of Action of HBO₂ for Persistent Post-Concussive Symptoms after Mild Traumatic Brain Injury (BIMA), sponsored by the Department of Defense, is a randomized, double-blind, sham-controlled trial of hyperbaric oxygen (HBO₂) in service members with persistent post-concussive symptoms following mild TBI, undergoing comprehensive assessments. The clinical EEG was assessed by neurologists for slow wave activity, ictal/interictal epileptiform abnormalities, and background periodic discharges. There is scant literature about EEG findings in this population, so we report baseline clinical EEG results and explore associations with other evaluations, including demographics, medication, neurological assessments, and clinical MRI outcomes. Seventy-one participants were enrolled: median age 32 years, 99% male, 49% comorbid PTSD, 28% with mTBI in the previous year, 32% blast injuries only, and 73% multiple injuries. All participants reported medication use (mean medications = 8, SD = 5). Slowing was present in 39%: generalized 37%, localized 8%, both 6%. No other abnormalities were identified. Slowing was not significantly associated with demographics, medication or neurological evaluation. Participants without EEG abnormalities paradoxically had significantly higher number of white matter hyperintensities as identified on MRI (p = 0.003). EEG slowing is present in more than one-third of participants in this study without evidence of associations with demographics, medications or neurological findings.
ClinicalTrials.gov Identifier: NCT01611194; https://clinicaltrials.gov/show/NCT01611194.
由国防部资助的“轻度创伤性脑损伤后持续性脑震荡后症状的高压氧治疗脑损伤及作用机制（BIMA）”是一项针对轻度创伤性脑损伤后出现持续性脑震荡后症状的军人进行的随机、双盲、假对照试验，这些军人正在接受全面评估。神经科医生对临床脑电图进行评估，以检查慢波活动、发作期/发作间期癫痫样异常以及背景周期性放电情况。关于该人群脑电图检查结果的文献很少，因此我们报告基线临床脑电图结果，并探讨其与其他评估指标的相关性，包括人口统计学特征、用药情况、神经学评估以及临床磁共振成像结果。共招募了71名参与者：年龄中位数为32岁，99%为男性，49%合并创伤后应激障碍，28%在过去一年中有轻度创伤性脑损伤，32%仅遭受爆炸伤，73%有多处损伤。所有参与者均报告正在用药（平均用药数量 = 8，标准差 = 5）。39%的人出现脑电减慢：广泛性减慢占37%，局限性减慢占8%，两者皆有的占6%。未发现其他异常情况。脑电减慢与人口统计学特征、用药情况或神经学评估无显著相关性。与脑电图无异常的参与者相比，磁共振成像显示有明显更多白质高信号的参与者数量出人意料地多（p = 0.003）。在本研究中，超过三分之一的参与者存在脑电减慢，且没有证据表明其与人口统计学特征、用药情况或神经学检查结果存在关联。
ClinicalTrials.gov标识符：NCT01611194；https://clinicaltrials.gov/show/NCT01611194 。
