Shimizu Keisuke, Luo Yi-Jyun, Satoh Noriyuki, Endo Kazuyoshi
Japan Agency for Marine-Earth Science and Technology, Yokosuka, Kanagawa 237-0061, Japan
Marine Genomics Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa 904-0495, Japan.
Biol Lett. 2017 Aug;13(8). doi: 10.1098/rsbl.2017.0254.
In molluscs, two homeobox genes, () and (), are transcription factors that are expressed in correlation with shell development. They are expressed in the regions between shell-forming and non-shell-forming cells, likely defining the boundaries of shell-forming fields. Here we investigate the expression of two transcription factors in the brachiopod We find that is expressed in larval mantle lobes, whereas is expressed in larval tentacles. We also demonstrate that the embryonic shell marker mantle peroxidase () is specifically expressed in mantle lobes. Our results suggest that and are possibly involved in brachiopod embryonic shell development. We discuss the evolutionary developmental origin of lophotrochozoan biomineralization through independent gene co-option.
在软体动物中，两个同源异型盒基因，（）和（），是与贝壳发育相关表达的转录因子。它们在形成贝壳和不形成贝壳的细胞之间的区域表达，可能界定了贝壳形成区域的边界。在这里，我们研究了两种转录因子在腕足动物中的表达。我们发现，在幼虫的外套叶中表达，而在幼虫的触须中表达。我们还证明，胚胎贝壳标记物外套过氧化物酶（）在外套叶中特异性表达。我们的结果表明，和可能参与了腕足动物胚胎贝壳的发育。我们通过独立的基因选择讨论了触手冠动物生物矿化的进化发育起源。
